DESCRIPTION:
A colorless or almost colorless clear liquid.
SPECIFICATION:
100ml:400mg
INDICATIONS:
Various anaerobic organisms infection: septicemia, osteomyelitis, pelvic inflammation, peritoneum inflammation, lung infection, sinusitis, oral cavity inflammation, prevent infection after operation: infection after colon and recta operation; various anaerobic organisms infection etc after intestines operation and department of gynecology operation.
USAGE AND DOSAGE:
1. Cure various anaerobic organisms infection : drip-infusion slowly ，1 time per day, 0．8g every time， in successive 5-6 days.
2. Prevent anaerobic organisms infection after operation: total dosage 1.6g, drip-infusion slowly in one or two times, the first time is 2 to 4 hours before operation, the second time is during the operation or 12 to 24 hours after the operation.
ADVERSE REACTION:
TINIDAZOLE has very little adverse reaction, it is mainly nausea, vomiting, upper abdominal pain, appetite decrease and metallic taste. May be headache, vertigo, tetter itch, constipation and general malaise. In additional may be acute circumscribed edema, neutrocytopenia, disulfiram-like reaction and black urine, drip position appears gently phlebitis. High dosage can cause epileptic seizure and peripheral neuropathy.
Contraindications: The usage is contraindicated in individuals with an allergic reaction to this medicine, or patients who suffer blood disease, neuropath.
PRECAUTION:
1.Drip-infusion of this product should be slowly when the concentration is 2mg/ml, the drip time is not less than 2mg/ml the speed should be decreased by 1-2 times. The drug should not be contact with pinhead including aluminium and bloster, avoid driping together with other drugs.
2.carcinogenesis and mutagenesis: animal test or in virto assay detect this product can lead to carcinogenesis and mutagenesis. but lack of document in human body.
3.if happened adverse reactions of central nervous system, should drug withdrawal in time.
4.it can interact the analysis result of amino acid, lactate dehydrogenase, triacylglycerol, hexokinase, the mV decreased by zero.
5.drinking wine is forbidden if taking this medicine, it can cause acetaldehyde accumulation in the body, interfere oxidative process of alcohol, leading to disulfiram-like reaction, patients may appears abdominal part spasm, nausea, vomiting, headache, prosopo-flush.
6.metabolism of the drug step down in hypohepatia patients, the drug and metabolin accumulated in the body. The dosage should be reduce, also monitoring blood drug level
7.this product can keep on cleaning from gastric juice, place some into gastric canal as suction reduced pressure, it can cause blood drug level decreased. When hematodialysis, the drug and metabolin can be cleared immediately, so it is not need to reduce the dosage
8.The patients monilia infection should use this drug, symptom will become more serious. Using anti-fungus treat simultaneously.
DRUG INTERACTION:
1. the drug can restrain metabolism of warfrin and other oral anticoagulant drug, strengthening their affection, causing time longer of thrombozyme,
2.when together use with induce hepatic microsomal enzyme such as phenytion and Phenobarbital, it can strengthen metabolism of the drug, descend the blood concentration, slow phenytion excrete.
3.when together use with inhibit hepatic microsomal enzyme such as cimetidine, it can slow metabolism and excretion of this drug in the liver, prolong blood elimination t1/2, if should be adjust the dosage according to blood concentration.
4.the drug interact metabolism of Disulfiram, both together use, the patients may appears psychiatric symptom, so the patients must not use the drug when administrated Disulfiram during 2 weeks.
5.this drug can interact the test result of blood serum aminopherase and lactic acid dehydrogenase, descend the level of cholesterol and triacylglycerol.
STORAGE: Stored in the closed container.
PACKAGE: glass injection bottle
EXPIRY DATE: two years
